10-Year Fracture Risk Calculator version 2.0

On what data is this model based?
This model uses several easily ascertained items plus bone mineral density (BMD) to calculate 10-year absolute fracture risk. The model begins by assigning the average fracture rate based on the patient's age. These population rates come from a publication that used US hospital discharge data for 2006. 1 The model calculates differences between the patient and the reference population in several clinical risk factors including bone mineral density (BMD). Each risk factor's relative risk is used to modify the expected fracture rate. The risk factors and relative risks have been have been closely aligned to those used in FRAX™ 2.

Why use a 10 year risk model?
Excellent risk-assessment models 3,4 exist for other diseases and have been translated into computer software that calculates absolute risk of event from multiple variables. These models include the one widely used to predict 5- and 10-year risks for breast cancer 3 and the National Cholesterol Education Program's model for predicting 10-year risk of coronary heart disease.4 Both models have been used in developing best practice guidelines, are widely recommended to guide therapeutic intervention, and are well accepted by clinicians. Cost-effectiveness analyses 5 and treatment recommendations based on these analyses 6 have now been published for osteoporosis drugs.

Are there other web-based fracture risk models?
The WHO FRAX™ model essentially replaces all previous web-based models because it has been extensively validated.

How does the current FORE model differ from the WHO FRAX™ model?
The FORE model and FRAX™ model use the same input variables, the same base fracture rates, and the same relative risks (multipliers). 2 Both can be applied to men and 4 different ethnicities. Both output the 10-year risk of hip and any one of 4 fractures (hip, wrist, humerus, clinical spine). One major difference is that the FORE model provides a graphic display of risk, comparing it to the expected risk, and categorizing it as low, medium, or high. A second difference is the FRAX™ model performs more adjustments for interactions between variables. Thus, users of these models should get very similar but not identical results.

Don't the types of fracture change with age?
The FORE and FRAX™ models provide 10-year absolute fracture risk for a hip fracture and for any one of 4 fractures (hip, spine, humerus, or wrist). The mix of fractures changes with age: at 45-49 years, hip fractures constitute only 7% but increase to 50% at 75 years.7 In contrast, the proportion of wrist fractures decreases with age, from 60% among the younger group to 26% among the older.

Why weren't other fractures included?
Both the FORE and FRAX™ models include four clinical osteoporotic fracture locations (i.e., spine, wrist, humerus, and hip) for several reasons: low BMD is a demonstrated risk factor for these fracture types;7 these fractures constitute the majority of osteoporotic (fragility-type) fractures;8 accurate rates of fracture incidence for the age range of interest were available from reliable published data1 and these fractures are costly to treat and can seriously alter quality of life.9

Why aren't other clinical risk factors included?
Both the FORE and FRAX™ models aim to keep the model data entry simple and in an easily understood format. Both use risk factors whose individual contributions to fracture risk have been estimated in large epidemiologic studies using multivariable models; the risk factors are the same as those used in cost-effectiveness analyses.5

Won't the WHO FRAX™ model replace the FORE model?
The WHO model is the standard in the field and has been incorporated into BMD reporting. In the FORE model, we have tried, as much as possible, to use the rates and relative risks that appear in the WHO model. 2 The FORE model adds graphic display and categorization of risk—that should be helpful in explaining risks and need for treatment to patients.

How should this model help in counseling patients and making decisions?
Models could promote awareness of the need for treatment among overlooked women in their 60s who have a number of risk factors but no clinically apparent osteoporosis (i.e. T-score not <-2.5). Fracture models appear to have the greatest value in solving the common clinical conundrum of osteopenia in healthy, early postmenopausal women. Giving a patient her absolute risk and discussing risk reduction expected from treatment in an easily understandable context enriches the quality and accuracy of information both clinicians and patients use for making decisions.

Can the model be used for men? For different ethnicities?
Both FORE and FRAX™ models can be used for men and for 4 different ethnicities (Caucasian, Hispanic, Black, Asian). Simply select gender and race/ethnicity in the input fields.

What if the patient is being treated for osteoporosis?
This model is based on fracture rates in untreated women and does not account for osteoporosis treatment effects. Estimates of the fracture risk reduction from regular long-term bisphosphonate therapy are in the order of 25-35%. 5,6,10 Recently, Leslie et al 11, on the basis of a large population study, concluded that "the FRAX tool can be used to predict fracture probability in women currently or previously treated for osteoporosis". In that study, bisphosphonate use did not substantially change the categorization of women in the population to low, medium, or high risk.